Chen shixing， Senior Engineer

E-mail：sxchen2025@shu.edu.cn

Personal Profile：

Dr. Chen has conducted systematic and in-depth research on the design and fabrication of sensing platforms based on fluorescence, electrochemistry, semiconductors, graphene, and related technologies. His research outcomes have been effectively translated into applications in disease diagnosis and treatment, establishing novel methodologies for the early detection and intervention of various diseases. He has published over 30 papers in prestigious journals such as Nano Letters, Chemical Science, Analytical Chemistry, and ACS Sensors, and has filed more than 30 invention patent applications, of which 10 have been granted, including 3 PCT US patents. He has led 8 research projects and served as a key technical contributor to several major research programs. As a co-founder, he spearheaded the commercialization of a key R&D program outcome, securing tens of millions of RMB in funding. Subsequently, as R&D Director at Geno Biotech Co., Ltd., he obtained multiple medical device registration certificates and oversaw the generation of hundreds of millions of RMB in output value.

Research Interests：

a.Application of intelligent sensors in the medical field

b.Development of small intelligent devices

c.Synthesis and performance characterization of organic/inorganic nanomaterials

Education：

2016: PhD, Shanghai Institute of Applied Physics, Chinese Academy of Sciences

2011: Bachelor’s Degree, Dalian Medical University

Work Experience：

January 2026 – Present: Senior Engineer, Shanghai University

June 2022 – July 2025: R&D Director, Jiangsu Geno Biotech Co., Ltd.

July 2016 – April 2022: Associate Researcher, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences

Research Achievements & Awards：

R&D products won the "2022 Innovative Technology Product for Tumor Markers", "2023 Innovative Technology Product for Tumor Markers", "3rd Prize of Qipu Award at the 5th China Health Industry Innovation Platform", and "Future Star of Medical Device Group in the 2024 Qipu Seed List".

Research Projects：

1. National Natural Science Foundation of China (Young Scientists Fund): Development of a multi-channel silicon nanowire FET biosensor for early diagnosis of pulmonary tuberculosis , January 2020 – December 2022, Principal Investigator.

2. National Key R&D Program: Research on micro-nano mechanical structure-based biochemical sensing , July 2017 – December 2021, Sub-project Leader.

3. Open Fund of Key Laboratory: Rapid recognition technology for mercury/lead ions in environmental water , June 2017 – September 2019, Principal Investigator.

4. National Key R&D Program: Sensitive signal conversion mechanisms and ultra-high sensitivity detection methods , July 2017 – June 2022, Sub-project Leader.

5. Major Instrument Project of Chinese Academy of Sciences: Exosome electrochemical analyzer based on silicon nanowires , January 2022 – December 2024, Task Leader.

Representative Publications：

1.Chen, S.X., Su J., Zhao, Z.H., Shao, Y; Dou, Y.Z., Li, F., Deng, W.P., Shi, J.Y., Li ,Q., Zuo, X.L., Song, S.P., and Fan, C.H. DNA Framework-Supported Electrochemical Analysis of DNA Methylation for Prostate Cancers，Nano Letters , 2020, 20(10): 7028-7035.（IF=11.19）

2.Chen, S.X., Dou YZ; Zhao ZH; Li FW; Su J; Fan CH; Song SP. High-Sensitivity and High-Efficiency Detection of DNA Hydroxymethylation in Genomic DNA by Multiplexing Electrochemical Biosensing, Analytical Chemistry, 2016, 88(7): 3476-3480.（IF=6.98）

3.Chen, S.X., Li FW; Fan CH; Song SP. Graphene-based nanoprobes for molecular diagnostics, Analyst, 2015, 140(19): 6439-51.（IF=4.62）

4.Zhihan Zhao ,Shixing Chen, Zhixiao Liu, Jing Su, Junhong Lü, Lihong Hao, Yanzhi Dou, Lihua Wang, Shiping Song., T7 Endonuclease I-mediated single-base mismatch biosensing strategy for high-resolution quantitative analysis of 5-hydroxymethylcytosine in genomic DNA , Journal of the American Chemical Society Au, 2025, 5, 3, 1320-1327 ( IF=8.6)

5.Su, J., Chen, S.X., Dou, Y.Z., Zhao, Z.H., Jia, X.L., Ding, X.T., and Song, S.P. Smartphone-Based Electrochemical Biosensors for Directly Detecting Serum-Derived Exosomes and Monitoring Their Secretion. Analytical Chemistry, 2022, 45-50.（IF=6.98）

6.Zhao, Z. H., Chen, S. X., Wang, J. B., Su, J., Xu, J. Q., Mathur, S. J., Fan, C. H. & Song, S. P. Nuclease-free target recycling signal amplification for ultrasensitive multiplexing DNA biosensing. Biosens Bioelectron,2017, 94, 605-608. （IF=10.62）

7.Anran Gao, Fuwen Wang, Zishuo Fan, Shixing Chen, Kejin Wu ., Reliable breast cancer miRNAs detection with enhanced silicon nanowire biosensor by PNA probe and optical calibration, Sensors & Actuators: B. Chemical , 2024 135011. ( IF=9.2)

8.Xinwu Xie, Jinbiao Ma, Hao Wang, Zhen Cheng, Tie Li, Shixing Chen, Yaohua Du, Jianguo Wu, Can Wang and Xinxi Xu., A self-contained and integrated microfluidic nano-detection system for the biosensing and analysis of molecular interactions. Lab Chip, 2022,22, 1702-1713. （IF=7.5）

9.Jinbiao Ma, DuCan Wang, Xinwu Xie, Hao Wang, Tie Li, Shixing Chen, Lixia Zhang, Shun Mao, Xiaohong Zhou., Rapid and Sensitive Detection of Mycobacterium tuberculosis by an Enhanced Nanobiosensor. ACS Sens. 2021, 6, 9, 3367–3376 （IF=7.71）

10.Su J; Liu WH; Chen, S. X., Deng WP; Dou YZ; Zhao ZH; Li J; Li ZH; Yin H; Ding XT; Song SP. A Carbon-Based DNA Framework Nano-Bio Interface for Biosensing with High Sensitivity and a High Signal-to-Noise Ratio, ACS Sensor, 2020, 5(12): 3979-3987.（IF=7.71）

Representative Patents：

1. A Microfluidic Chip – CN202420854756.1

2. A Target Concentration Detection Method Based on Silicon Nanowire Field-Effect Biochemical Sensors – CN202111031603.4

3. A Measuring Device and Method for Resistance Value of Silicon Nanowire FET Sensors – CN202110985591.2

4. A Nucleic Acid Rapid Detection Kit and Detection Method for Novel Coronavirus Screening – CN202311586384.5

5. A Device and Method for Regulating Sensitivity of Silicon Nanowire Sensors by Light – CN202010073580.2

6. A Fluid Flow Rate Stabilization System – CN201910950177.0